Gene

irs2b

ID
ZDB-GENE-081104-462
Name
insulin receptor substrate 2b
Symbol
irs2b Nomenclature History
Previous Names
  • irs2
  • si:dkeyp-24d6.1 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Knuth et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-irs2b
    Mazzaferro et al., 2025
    MO1-irs2bN/AZasu et al., 2022
    1 - 2 of 2
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    Human Disease
    Associated With irs2b Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
    1 - 1 of 1
    Associated With irs2b Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Domain IPR001849 Pleckstrin homology domain
    Domain IPR002404 IRS-type PTB domain
    Family IPR039011 Insulin receptor substrate
    Homologous_superfamily IPR011993 PH-like domain superfamily
    1 - 4 of 4
    Domain Details Per Protein
    Protein Additional Resources Length Insulin receptor substrate IRS-type PTB domain PH-like domain superfamily Pleckstrin homology domain
    UniProtKB:A0A0R4IKQ9 InterPro 1062
    1 - 1 of 1
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 9
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA irs2b-201 (1) Ensembl 7,379 nt
    1 - 1 of 1
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    Construct Regulatory Region Coding Sequence Species Tg Lines Citations
    Tg(hsp70l:LOXP-mCherry-STOP-LOXP-dnirs2b-EGFP,cryaa:Cerulean)
    • Danio rerio
    1Ye et al., 2016
    Tg(Tru.Tyrp1:dnirs2b-GFP,myl7:mCherry)
    • Danio rerio
    • Takifugu rubripes
    1Zhang et al., 2018
    1 - 2 of 2
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    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACDKEYP-24D6ZFIN Curated Data
    Contained inFosmidCH1073-391C6ZFIN Curated Data
    1 - 2 of 2
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanIRS213
    Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    MouseIrs28
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (1)
    Citations
    1 - 10 of 14
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