Gene
irs2b
- ID
- ZDB-GENE-081104-462
- Name
- insulin receptor substrate 2b
- Symbol
- irs2b Nomenclature History
- Previous Names
-
- irs2
- si:dkeyp-24d6.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Knuth et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irs2b | Mazzaferro et al., 2025 | |
| MO1-irs2b | N/A | Zasu et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IKQ9 | InterPro | 1062 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:LOXP-mCherry-STOP-LOXP-dnirs2b-EGFP,cryaa:Cerulean) |
| 1 | Ye et al., 2016 | ||
| Tg(Tru.Tyrp1:dnirs2b-GFP,myl7:mCherry) |
| 1 | Zhang et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-24D6 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-391C6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_695654 (1) | 5184 nt | ||
| Genomic | GenBank:BX465867 (1) | 170425 nt | ||
| Polypeptide | UniProtKB:A0A0R4IKQ9 (1) | 1062 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Yu, W., Luo, R., He, C., Li, Z., Yang, M., Zhou, J., He, J., Chen, Q., Song, Z., Cheng, S. (2024) Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Frontiers in pharmacology. 15:13391781339178
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Yang, F., Qiu, W., Li, R., Hu, J., Luo, S., Zhang, T., He, X., Zheng, C. (2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere. 213:559-567
- Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7
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