Gene
irs2b
- ID
- ZDB-GENE-081104-462
- Name
- insulin receptor substrate 2b
- Symbol
- irs2b Nomenclature History
- Previous Names
-
- irs2
- si:dkeyp-24d6.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Knuth et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IKQ9
|
1062 |
Interactions and Pathways
No data available
Plasmids
No data available