Gene
socs1a
- ID
- ZDB-GENE-040801-205
- Name
- suppressor of cytokine signaling 1a
- Symbol
- socs1a Nomenclature History
- Previous Names
-
- socs1 (1)
- zgc:91868
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Acts upstream of or within several processes, including positive regulation of T cell migration; regulation of signal transduction; and regulation of tyrosine phosphorylation of STAT protein. Is expressed in several structures, including brain; digestive system; musculature system; pleuroperitoneal region; and visual system. Used to study hyperinsulinism and steatotic liver disease. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91868 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-socs1a | N/A | (2) |
| MO2-socs1a | N/A | (2) |
| MO3-socs1a | N/A | (2) |
| TALEN1-socs1a | (3) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammatory syndrome, familial, with or without immunodeficiency | 619375 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SH2 domain | SH2 domain superfamily | SOCS1, SH2 domain | SOCS box domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DEF9 | InterPro | 201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
socs1a-201
(1)
|
Ensembl | 1,154 nt | ||
| mRNA |
socs1a-202
(1)
|
Ensembl | 642 nt |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-socs1a | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-202L16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91868 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193000 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003467 (1) | 1170 nt | ||
| Genomic | GenBank:BX470132 (1) | 163404 nt | ||
| Polypeptide | UniProtKB:Q6DEF9 (1) | 201 aa |
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Banks, K.M., Lan, Y., Evans, T. (2021) Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA. Cell Reports. 34:108632
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- Apaydin, D.C., Jaramillo, P.A.M., Corradi, L., Cosco, F., Rathjen, F.G., Kammertoens, T., Filosa, A., Sawamiphak, S. (2020) Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance. Cell Reports. 33:108404
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
- Kim, D.H., Jung, I.H., Kim, D.H., Park, S.W. (2019) Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span. PLoS One. 14:e0220581
- Shi, C., Lu, Y., Zhai, G., Huang, J., Shang, G., Lou, Q., Li, D., Jin, X., He, J., Du, Z., Gui, J., Yin, Z. (2019) Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity. Journal of molecular cell biology. 12(4):291-304
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