FIGURE

FIGURE 4

ID

ZDB-FIG-200619-49

Publication

Mazzola et al., 2020 - Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects

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FIGURE 4

The down‐regulation of rad21 in zebrafish enhances the expression of runx1 and its downstream targets gata1a and spi1b. A‐D, RT‐qPCR analyses of 48 hpf ctrl‐ and rad21‐MO‐injected embryos. The expression of both P1 (A) and P2runx1 (B) isoforms and of runx1 targets gata1a (C) and spi1b (D) was increased following rad21‐MO injection in comparison to controls at 48 hpf. One‐way ANOVA with Bonferroni correction, ^***P < .001, ^**P < .01, ^*P < .05, n.s: non‐significant

Expression Data

Genes:	gata1a runx1 spi1b
Fish:	AB + MO2-rad21a
Knockdown Reagent:	MO2-rad21a
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-rad21a
Knockdown Reagent:	MO2-rad21a
Observed In:	whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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