FIGURE

FIGURE 2

ID

ZDB-FIG-200619-53

Publication

Mazzola et al., 2020 - Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 2

runx1 expression is specifically reduced following nipblb down‐regulation. A‐C WISH analyses of runx1 expression at the stage of 30 hpf in embryos injected with control morpholino (ctrl‐MO) (A), nipblb‐MO (B) and nipblb‐MO with runx1‐mRNA (C). The runx1 expression in the caudal region (higher magnification in the box) is reduced following nipblb down‐regulation and rescued in embryos co‐injected with nipblb‐MO and runx1 mRNA. E‐F, RT‐qPCR analyses of the P1runx1 (D) and P2runx1 (E) isoforms in ctrl‐MO‐, nipblb‐MO‐ and nipblb‐MO/runx1mRNA‐injected embryos at 48 hpf. Scale bars indicate 100 μm. One‐way ANOVA with Bonferroni correction, ^**P < .01, ^*P < .05, n.s: non‐significant

Expression Data

Gene:	runx1
Fish:	AB + MO3-nipblb
Knockdown Reagent:	MO3-nipblb
Anatomical Term:	ventral wall of dorsal aorta
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-nipblb
Knockdown Reagent:	MO3-nipblb
Observed In:	ventral wall of dorsal aorta
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.