FIGURE

Figure 2

ID

ZDB-FIG-200129-28

Publication

Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

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Figure 2

Expression of selected markers in various genetic background zebrafish fed with different diets. Expression of lipogenic enzymes (agpat, fasn, and pap), lipogenic factors (pparg, srebf1, and chrebp), and cell cycle/proliferation-related genes (ccne1, cdk1, and cdk2) in (A–C) WT, (D–F) HBx(p53-), (G–I) Src(p53-), and (J–L) HBx,Src(p53-) fish after eight weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT). The number of fish is 20 for each group, and the number of experimental replicates for qPCR analysis is three. Expression fold change compared to WT_NOR control. Statistical analysis of results was performed using a two-tailed Student’s t-test. Asterisks (*) represent level of significance: * p-value ≤ 0.05; ** p-value ≤ 0.01; *** p-value ≤ 0.001; **** p-value ≤ 0.0001.

Expression Data

Genes:	agpat4 ccne1 cdk1 cdk2 fasn mlxip pparg srebf1
Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Observed In:	liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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