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Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

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Figure 2

Expression of selected markers in various genetic background zebrafish fed with different diets. Expression of lipogenic enzymes (agpat, fasn, and pap), lipogenic factors (pparg, srebf1, and chrebp), and cell cycle/proliferation-related genes (ccne1, cdk1, and cdk2) in (A–C) WT, (D–F) HBx(p53-), (G–I) Src(p53-), and (J–L) HBx,Src(p53-) fish after eight weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT). The number of fish is 20 for each group, and the number of experimental replicates for qPCR analysis is three. Expression fold change compared to WT_NOR control. Statistical analysis of results was performed using a two-tailed Student’s t-test. Asterisks (*) represent level of significance: * p-value ≤ 0.05; ** p-value ≤ 0.01; *** p-value ≤ 0.001; **** p-value ≤ 0.0001.

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