FIGURE

Figure 3

ID

ZDB-FIG-200129-29

Publication

Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

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Figure 3

Histopathological changes in various genetic background zebrafish fed with different diets. Representative H&E stain images and histopathologic change statistics of (A–D) WT, (E–H) HBx(p53-), (I–L) Src(p53-), and (M–P) HBx, Src(p53-) fish after 8 weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT) starting at 3 months of age, and scarified at 5 months. The histopathologic change consists of percentages in five states: normal, steatosis, hyperplasia, dysplasia, and hepatocellular carcinoma (HCC). The number of fish is represented as N on top of each bar. The scale bar is 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tp53^zdf1/zdf1; nn1002Tg tp53^zdf1/zdf1; nn1003Tg tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Conditions:	increased food availability high fat
Observed In:	liver liver hepatocellular carcinoma liver hepatocyte liver lipid
Stage:	Adult

Phenotype Detail

Acknowledgments

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