Gene
pparg
- ID
- ZDB-GENE-990415-213
- Name
- peroxisome proliferator-activated receptor gamma
- Symbol
- pparg Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within triglyceride homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 80 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017619 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial partial lipodystrophy type 3 | Alliance | Lipodystrophy, familial partial, type 3 | 604367 |
| obesity | Alliance | Obesity, severe | 601665 |
| type 2 diabetes mellitus | Alliance | Insulin resistance, severe, digenic | 125853 |
| type 2 diabetes mellitus | Alliance | {Diabetes, type 2} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR022590 | Peroxisome proliferator-activated receptor gamma, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003074 | Peroxisome proliferator-activated receptor |
| Family | IPR003077 | Peroxisome proliferator-activated receptor gamma |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma | Peroxisome proliferator-activated receptor gamma, N-terminal | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A6XMH6
|
527 |
Interactions and Pathways
Plasmids