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ZFIN ID: ZDB-FIG-191230-448
Tuttle et al., 2019 - Retrograde Ret signaling controls sensory pioneer axon outgrowth. eLIFE   8 Full text @ Elife
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Protruding-mouth

Figure 6 Sorafenib induces pLLG axon truncation similar to that found in Ret genetic loss-of-function at 72 hpf.

Treatment with 5 μM sorafenib from 24 to 72 hpf induced axon truncations in wild-type siblings (0.50 ± 0.06; n = 44) not significantly different than untreated ret homozygous mutants (0.53 ± 0.03; n = 17; p=0.95 by one way ANOVA with post-hoc Tukey test) or sorafenib-treated ret homozygous mutants (0.50 ± 0.05; n = 16; p=0.92). Error bars represent S.E.M., N.S. = Not significant.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mapk8ip3nl7/nl7; nl1Tg control Protruding-mouth posterior lateral line ganglion axon truncated, abnormal
mapk8ip3nl7/nl7; nl1Tg chemical treatment by environment: sorafenib Protruding-mouth posterior lateral line ganglion axon truncated, abnormal
nl1Tg chemical treatment by environment: sorafenib Protruding-mouth posterior lateral line ganglion axon truncated, abnormal
Acknowledgments:
ZFIN wishes to thank the journal eLIFE for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Elife