FIGURE

Figure 6

ID

ZDB-FIG-191230-448

Publication

Tuttle et al., 2019 - Retrograde Ret signaling controls sensory pioneer axon outgrowth

Other Figures

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Figure 6

Sorafenib induces pLLG axon truncation similar to that found in Ret genetic loss-of-function at 72 hpf.

Treatment with 5 μM sorafenib from 24 to 72 hpf induced axon truncations in wild-type siblings (0.50 ± 0.06; n = 44) not significantly different than untreated ret homozygous mutants (0.53 ± 0.03; n = 17; p=0.95 by one way ANOVA with post-hoc Tukey test) or sorafenib-treated ret homozygous mutants (0.50 ± 0.05; n = 16; p=0.92). Error bars represent S.E.M., N.S. = Not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nl1Tg mapk8ip3^nl7/nl7; nl1Tg
Condition:	chemical treatment by environment: sorafenib
Observed In:	posterior lateral line ganglion axon
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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