FIGURE

Figure 6

ID

ZDB-FIG-191230-429

Publication

Fernando et al., 2019 - Ishige okamurae Extract and Its Constituent Ishophloroglucin A Attenuated In Vitro and In Vivo High Glucose-Induced Angiogenesis

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Figure 6

(A) IPA inhibits vascular endothelial growth factor receptor 2 (VEGFR-2) and its downstream signaling molecules. IPA attenuating high glucose-induced phosphorylation of VEGFR-2 and downstream signaling molecules extracellular signal-regulated kinase (ERK), protein kinase B (AKT), c-Jun N-terminal kinase (JNK), and endothelial nitric oxide synthase (eNOS) were detected using western blotting. (B) Quantitative evaluation of the protein expression. The effects of 30 mM glucose on the expression of each protein were compared to B (blank (0 mM glucose + 0 µM IPA)). The effects of IPA on high glucose-induced protein expression were normalized to C (control (30 mM glucose + 0 µM IPA)). ns; not significant, * p ˂ 0.05, ** p ˂ 0.01, *** p ˂ 0.001, ^#p ˂ 0.05, ^##p ˂ 0.01, ^###p ˂ 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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