ZFIN Image: Fernando et al., 2019, Figure 6

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Figure Caption

Figure 6

(A) IPA inhibits vascular endothelial growth factor receptor 2 (VEGFR-2) and its downstream signaling molecules. IPA attenuating high glucose-induced phosphorylation of VEGFR-2 and downstream signaling molecules extracellular signal-regulated kinase (ERK), protein kinase B (AKT), c-Jun N-terminal kinase (JNK), and endothelial nitric oxide synthase (eNOS) were detected using western blotting. (B) Quantitative evaluation of the protein expression. The effects of 30 mM glucose on the expression of each protein were compared to B (blank (0 mM glucose + 0 µM IPA)). The effects of IPA on high glucose-induced protein expression were normalized to C (control (30 mM glucose + 0 µM IPA)). ns; not significant, * p ˂ 0.05, ** p ˂ 0.01, *** p ˂ 0.001, ^#p ˂ 0.05, ^##p ˂ 0.01, ^###p ˂ 0.001.

Acknowledgments

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