FIGURE

Fig. 5

ID

ZDB-FIG-191230-22

Publication

Hu et al., 2019 - Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection

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Fig. 5

Immune genes expression in tlr2^+/− and tlr2^−/− fish lines infected with Mm. The expression levels of il1b (a), tnfa (b), tnfb (c), irg1l (d), fosl1a (e), cebpb (f), cxcl11aa (g) and cxcl11ac (h) were determined at 4dpi by qPCR. Data (mean ± SEM) are derived from at least three biological replicates (n = 10 embryos per group) and expressed relative to their corresponding mock injection (PBS) control, which is set at 1. Statistical significance of differences was determined by two-way ANOVA with Tukey’s Multiple Comparison test as a post-hoc test. *P < 0.05, **P < 0.01, ***P < 0.001

Expression Data

Genes:	cebpb cxcl11.1 cxcl11.3 fosl1a il1b irg1l tnfa tnfb (all 8)
Fish:	tlr2^{sa19423/sa19423} tlr2^sa19423/+
Condition:	bacterial treatment by injection: Mycobacterium marinum
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tlr2^{sa19423/sa19423} tlr2^sa19423/+
Condition:	bacterial treatment by injection: Mycobacterium marinum
Observed In:	defense response to bacterium whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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