FIGURE

Fig. S7

ID

ZDB-FIG-191126-17

Publication

Hsu et al., 2019 - Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

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Fig. S7

Cdk2 D145N inhibits neutrophil motility and chemotaxis and the working model.

(A) Representative images and (B) quantification of velocity of neutrophils in 3 dpf zebrafish embryos from the WT or D145N line in a LTB4 bath. Scale bar: 200 μm. (C) Representative images and (D) quantification of velocity of neutrophil motility in 3 dpf zebrafish embryos from the WT or D145N line in the caudal hematopoietic tissue. Scale bar: 200 μm. Assays were performed with at least 3 individual founders with 3 biological repeats each containing at least 3 fish per group. Result is presented as mean ± s.d., Mann–Whitney test. (E) Working model of how miR-199 inhibits neutrophil migration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA