FIGURE

Fig 1

ID

ZDB-FIG-190723-1968

Publication

Progatzky et al., 2019 - Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans

Other Figures

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Fig 1

Kinetic profile of mucosal proinflammatory cytokine responses after zebrafish gill, mouse, and human nasal stimulation with R848. A-C, Schematics showing mucosal administration of TLR agonists and sampling of mucosal tissue/fluids to assess responses. D, G, J, M, and P, qRT-PCR analysis of zebrafish gills (n = 5, representative of 3 experiments). Values are presented as means ± SEMs. Two-way ANOVA followed by the Sidak multiple comparison test was used. E, H, K, N, and Q, qRT-PCR analysis of mouse nasal mucosa (n = 4-10 pooled from 2 independent experiments). Values are presented as means ± SEMs. Two-way ANOVA followed by the Sidak multiple comparison test was used. F, I, L, O, and R, Soluble protein mediator analysis of human nasal samples (n = 9). Values are presented as geometric means and 95% CIs. Paired t tests on log₁₀-transformed area under the curve values were used. *P < .05, **P < .01, and ***P < .001.

Expression Data

Genes:	ifng1r ifnphi1 il1b il6 tnfa
Fish:	WT
Condition:	chemical treatment: resiquimod
Anatomical Term:	gill
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment: resiquimod
Observed In:	gill
Stage:	Adult

Phenotype Detail

Acknowledgments

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