ZFIN ID: ZDB-GENE-060210-1
Gene Name: interferon gamma related
Gene Symbol: ifng1r    Nomenclature History

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Previous Names: ifng1-1, Ifng1 (1), Ifngamma1 (1), si:ch211-266a5.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have interferon-gamma receptor binding activity. Involved in defense response to Gram-negative bacterium and immune response. Predicted to localize to extracellular region. Is expressed in digestive system; gill; reproductive system; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune hypersensitivity disease (multiple); bone disease (multiple); eczema herpeticum; and leukemia (multiple). Orthologous to human IFNG (interferon gamma).
Genome Resources: Alliance (1),  Gene:553965 (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb209 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb210 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa1406 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12073 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18777 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ifng1r 1
    CRISPR2-ifng1r
    1
    CRISPR3-ifng1r
    1
    MO1-ifng1r N/A 4
    PHENOTYPE
    Data: text only from Sieger et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH ifng1r HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aplastic anemia Alliance {Aplastic anemia} 609135
    tuberous sclerosis 2 Alliance {TSC2 angiomyolipomas, renal, modifier of} 613254
    {AIDS, rapid progression to} 609423
    {Hepatitis C virus, response to therapy of} 609532
    {Tuberculosis, protection against} 607948
    DISEASE ASSOCIATED WITH ifng1r VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to Gram-negative bacterium (more)
    Cellular Component extracellular region (more)
    Molecular Function interferon-gamma receptor binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ifng1r-201 (1)    Ensembl 513
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ifng1r No data available
    MARKER RELATIONSHIPS
    ifng1r Contained in: [BAC] CH211-266A5
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020793 (1) 513 nt
    Genomic GenBank:BX465210 (1) 171708 nt
    Select Tool
    Polypeptide UniProtKB:Q5TLE6 (1) 170 aa
    Sequence Information (all 7)
    ORTHOLOGY for ifng1r ( Chr: 4 )
    CITATIONS (65)