FIGURE

Fig. S2

ID

ZDB-FIG-181003-21

Publication

Yakulov et al., 2018 - CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury

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Fig. S2

Cilia and fluid flow are not required for pronephros repair

(a) Homozygous ift88(-/-) (ovl) zebrafish embryos were injured 3 days after fertilization, and fixed 2 and 6 hours after wounding. In situ hybridization was performed with the pronephros-specific marker cadherin17 (cdh17). At this stage, the embryos displayed prominent cysts and duct dilatations due to ciliary defects. The gap, clearly visible at 2 hours, was repaired 6 hours after injury. The results were confirmed in three independent experiments with at least 3 control and 3 mutant embryos (Scale bar, 100 μm). (b) Frames from a timelapse movie following the recovery in ift88(-/-) (ovl) embryo. The laser-induced injury was completely repaired over an 8-hour time course (Scale bar, 10 μm).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.