FIGURE

Fig. 7

ID

ZDB-FIG-180705-15

Publication

Liu et al., 2018 - Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

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Fig. 7

DHA rescues hematopoiesis in apoc2 mutants. a–c apoc2 mutant embryos were injected with free fatty acid docosahexaenoic acid (DHA), oleic acid (OA), or eicosapentaenoic acid (EPA) at 48 hpf. a o-Dianisine staining of 6.3 dpf larvae. b Representative bright field images and quantitative results of blood cell (yellow arrows) count in the caudal vein (outlined with white dashed lines) at 6.3 dpf. Mean ± SEM; n = 10 (WT), n = 8 (apoc2 mut, apoc2 mut + OA, and apoc2 mut + EPA), and n = 9 (apoc2 mut + DHA). ***P < 0.001 (Student’s t test). c In situ hybridization with cmyb/runx1 and β-globin probes. Scale bars, 100 μm in a; 50 μm in b; and 200 μm in c

Expression Data

Genes:	hbbe1.1 myb runx1
Fish:	AB apoc2^sd38/sd38 (AB)
Conditions:	chemical treatment by injection: docosahexaenoic acid chemical treatment by injection: icosapentaenoic acid chemical treatment by injection: oleic acid
Anatomical Terms:	caudal hematopoietic tissue erythroblast caudal hematopoietic tissue hematopoietic multipotent progenitor cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apoc2^sd38/sd38 (AB)
Conditions:	chemical treatment by injection: docosahexaenoic acid chemical treatment by injection: icosapentaenoic acid chemical treatment by injection: oleic acid
Observed In:	caudal hematopoietic tissue erythroblast caudal hematopoietic tissue hematopoietic multipotent progenitor cell caudal vein blood cell whole organism hemoglobin
Stage Range:	Protruding-mouth to Day 6

Phenotype Detail

Acknowledgments

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