FIGURE

Fig. 6

ID

ZDB-FIG-180522-10

Publication

Kimelman et al., 2017 - Regulation of posterior body and epidermal morphogenesis in Zebrafish by localized Yap1 and Wwtr1

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Fig. 6

Tp63 positive cells accumulate at the nascent fin fold in sibling but not mutant embryos.

Embryos were incubated with the anti-Tp63 antibody, and then co-stained with DAPI. (A) Embryos were collected at the indicated stages. Note the increase in Tp63-positive cells on the dorsal and ventral midline as the embryos age. (B–D) The Tp63-positive presumptive epidermis at the 18-somite stage (B) is one layer thick, but increases to multiple layers by the 24-somite stage in sibling (C) but not in yap1;wwtr1 double mutant embryos (D). Confocal images of the midline of the tailbud, with anterior to the left. The zoomed in images in panels B-D are of the dorsal side, and the arrows in the merged images point to the rare presumptive epidermis Tp63-negative cells.

Expression Data

Antibody:	Ab6-tp63
Fish:	WT yap1^bns19/bns19; wwtr1^bns35/bns35
Anatomical Term:	ectoderm
Stage Range:	14-19 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	yap1^bns19/bns19; wwtr1^bns35/bns35
Observed In:	ectoderm epidermis morphogenesis
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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