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ZFIN ID: ZDB-FIG-180110-18
Lim et al., 2017 - HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology   46:83-95.e6 Full text @ Exp. Hematol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Knockdown Reagent:
Anatomical Terms:
Stage: Prim-25
PHENOTYPE:
Fish:
Condition:
Knockdown Reagent:
Observed In:
Stage: Prim-25

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
il6 WT chemical treatment by environment: cobalt dichloride Prim-25 whole organism RTPCR
il6r WT chemical treatment by environment: cobalt dichloride Prim-25 whole organism RTPCR
myb WT control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-il6 control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-il6 chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
runx1 WT control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-il6 control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-il6 chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal
Prim-25 whole organism il6 expression increased amount, abnormal
Prim-25 whole organism il6r expression increased amount, abnormal
WT + MO1-il6 chemical treatment by environment: cobalt dichloride Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated
la2Tg; sd2Tg chemical treatment by environment: cobalt dichloride Prim-25 hematopoietic multipotent progenitor cell increased amount, abnormal
la2Tg; sd2Tg + MO1-il6 chemical treatment by environment: cobalt dichloride Prim-25 hematopoietic multipotent progenitor cell amount, ameliorated
Full text @ Exp. Hematol.