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ZFIN ID: ZDB-FIG-180110-9
Lim et al., 2017 - HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology   46:83-95.e6 Full text @ Exp. Hematol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Conditions:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Prim-25 to Long-pec
PHENOTYPE:
Fish:
Conditions:
Knockdown Reagents:
Observed In:
Stage Range: Prim-25 to Long-pec

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
myb WT control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
Long-pec hematopoietic stem cell ISH
WT chemical treatment by environment: cobalt dichloride Long-pec hematopoietic stem cell ISH
WT chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
runx1 WT control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO1-pdgfrb + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
WT + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment by environment: cobalt dichloride Long-pec hematopoietic stem cell myb expression increased amount, abnormal
WT chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal
WT + MO1-pdgfrb chemical treatment by environment: dimethyloxalylglycine Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated
WT + MO1-pdgfrb + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated
WT + MO2-vhl control Prim-25 ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal
Prim-25 ventral wall of dorsal aorta hematopoietic stem cell runx1 expression increased amount, abnormal
la2Tg; sd2Tg chemical treatment by environment: cobalt dichloride Long-pec hematopoietic multipotent progenitor cell increased amount, abnormal
la2Tg; sd2Tg + MO1-pdgfrb + MO2-vhl standard conditions Prim-25 hematopoietic multipotent progenitor cell decreased amount, ameliorated
la2Tg; sd2Tg + MO2-vhl standard conditions Prim-25 hematopoietic multipotent progenitor cell increased amount, abnormal
Full text @ Exp. Hematol.