Gene

il6r

ID

ZDB-GENE-080107-7

Name

interleukin 6 receptor

Symbol

il6r Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il6r Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections	618944
		[Interleukin 6, serum level of, QTL]	614752
		[Interleukin-6 receptor, soluble, serum level of, QTL]	614689

Associated With il6r Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site
Domain	IPR003961	Fibronectin type III
Family	IPR050379	Type I Cytokine Receptor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Long hematopoietin receptor, soluble alpha chain, conserved site	Type I Cytokine Receptor
UniProtKB:A0A7S9AT90 InterPro
UniProtKB:A0A7S9ATA7 InterPro
UniProtKB:A0A8M1PAC4 InterPro	604

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations