Gene

il6r

ID
ZDB-GENE-080107-7
Name
interleukin 6 receptor
Symbol
il6r Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have interleukin-11 binding activity and interleukin-11 receptor activity. Predicted to be involved in positive regulation of cell population proliferation. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; obesity; and stomach cancer. Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Orthologous to human IL6R (interleukin 6 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il6r Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections 618944
[Interleukin 6, serum level of, QTL] 614752
[Interleukin-6 receptor, soluble, serum level of, QTL] 614689
Associated With il6r Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Domain IPR003961 Fibronectin type III
Family IPR050379 Type I Cytokine Receptor
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like domain superfamily Immunoglobulin-like fold Long hematopoietin receptor, soluble alpha chain, conserved site Type I Cytokine Receptor
UniProtKB:A0A7S9AT90
UniProtKB:A0A7S9ATA7
UniProtKB:A0A8M1PAC4 604
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA il6r-201 (1) Ensembl 2,555 nt
mRNA il6r-202 (1) Ensembl 4,005 nt
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations