FIGURE

Fig. 1

ID

ZDB-FIG-171128-8

Publication

Hoodless et al., 2016 - Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

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Fig. 1

Injury of the zebrafish tailfin results in recruitment of neutrophils and macrophages to the injury site.

(a) The tailfin of 3?dpf Tg(mpx:EGFP)ⁱ¹¹⁴ and Tg(MPEG1:mCherry) embryos were transected (line of transection shown in red) and a region (0.5?mm length from the tip of the body of the fish) was selected in which to count recruited cells. (b) Temporal recruitment of neutrophils (Tg[mpx:EGFP]ⁱ¹¹⁴ [i, ii]) and macrophages (Tg[MPEG1:mCherry] [iii, iv]) post-injury was determined. (c) The numbers of inflammatory cells in each tailfin region were quantified. All time points after 0?h were significantly (p???0.05) different to the cell numbers at 0?h. All images at 80x magnification. ?40 fish per group, from 3 independent experiments. Data expressed as �S.E.M.

Expression Data

Genes:	GFP mCherry
Fish:	gl23Tg i114Tg
Condition:	transection: caudal fin
Anatomical Terms:	macrophage neutrophil
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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