Fig. S2
- ID
- ZDB-FIG-171117-29
- Publication
- Halluin et al., 2016 - Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade
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Sonic Hedgehog ligand (Shha) is required for habenular development. Whole-mount in situ hybridization against cxcr4b at 36 hpf (A,A?,B,B?) or brn3a at 48 hpf (C,C?,D,D?) showing heads (A-D) or the epithalamus (A?-D?) of wild type (A,A?,C,C?) or shhatbx392 embryos (B,B?,D,D?). While the expression of cxcr4b and brn3a is detected in the habenulae of all the wild type siblings (n = 8 and n = 14 respectively), the expression of both genes is strongly reduced in the epithalamus of shhatbx392 mutant embryos (B,B?, n = 12/13 and D,D?, n = 6/6). Embryos are viewed dorsally with anterior up. |
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Stage Range: | Prim-25 to Long-pec |