Gene

pou4f1

ID

ZDB-GENE-000523-2

Name

POU class 4 homeobox 1

Symbol

pou4f1 Nomenclature History

Previous Names

brn3.0
brn3a (1)
brn3b-pen (1)
etID22526.1 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in heart development. Predicted to localize to nucleus. Is expressed in nervous system. Orthologous to human POU4F1 (POU class 4 homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou4f1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Ataxia, intention tremor, and hypotonia syndrome, childhood-onset	619352

Associated With pou4f1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeodomain
Domain	IPR013847	POU domain
Family	IPR050255	POU domain transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Homedomain-like superfamily	Homeobox, conserved site	Homeodomain	Lambda repressor-like, DNA-binding domain superfamily	POU domain	POU domain transcription factor	POU-specific domain
UniProtKB:Q7SZN6 InterPro	366

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pou4f1-201 (1) Ensembl	Ensembl		2,732 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-pou4f1	polyclonal	pou4f1	IgG	Goat	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations