FIGURE

Fig. 4

ID

ZDB-FIG-171004-11

Publication

Demy et al., 2017 - Trim33 / Tif1-γ is essential for macrophage and neutrophil mobilisation to developmental or inflammatory cues

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Fig. 4

The basal migration in interstitial tissues of both macrophages and neutrophils is affected in moonshine mutants. In vivo 4D tracking of mCherry-positive macrophages and GFP-positive neutrophils in the head and anterior yolk sac area of mon^NQ039Tg(mpeg1:mCherryF; mpx:gfp) sibling (Sib) (A–A″) and mutant (Mut) (B–B″) embryos at 48 hpf. e, ear; l, lens; y, yolk sac; h, hindbrain; r, retina. Cell trajectories are shown in panels (A′,A″,B′,B″), with colour coding of speed (from 0 to 300 µm/h), and the number (Nb) of cells tracked per time point in each case is shown in C (as mean±s.d. for 80 time points). (D,E) Quantification of the mean±s.d. square displacement over time illustrates the migration defect of the mutant leukocytes.

Expression Data

Genes:	GFP mCherry
Fish:	i114Tg; ump2Tg trim33^{t30813/t30813}; i114Tg; ump2Tg
Anatomical Terms:	macrophage neutrophil
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	trim33^{t30813/t30813}; i114Tg; ump2Tg
Observed In:	macrophage macrophage migration neutrophil neutrophil migration
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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