FIGURE

Fig. 5

ID
ZDB-FIG-170517-38
Publication
Anelli et al., 2017 - Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression
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Fig. 5

Adult transgenic fish expressing BRAFV600E in thyrocytes develop invasive thyroid cancer similar to human PTC.

(A?B) Representative H&E and IHC staining using anti-thyroglobulin and anti-P-ERK antibodies performed on sagittal sections from control tg-TOM (A) and tumor bearing tg-BRAFV600E-TOM adult zebrafish at 12 mpf (B) (20X magnification). Arrows indicate sites of carcinoma invading skeletal muscle, inset is 40X magnification of skeletal muscle invasion. (C) High magnification photomicrographs of H&E-stained sections from tg-BRAFV600E-TOM animals. Key diagnostic features of papillary thyroid carcinoma are observed: nuclear grooves (arrows), elongated nuclei (arrows), desmoplastic stromal reaction (asterisk) and crowded nuclei (60X magnification).
Expression Data
Antibodies:
Fish:
Anatomical Term:
Stage: Adult

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
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