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Fig. 5

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ZDB-IMAGE-170517-37

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Publication

Anelli et al., 2017 - Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression

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Fig. 5

Adult transgenic fish expressing BRAF^V600E in thyrocytes develop invasive thyroid cancer similar to human PTC.

(A–B) Representative H&E and IHC staining using anti-thyroglobulin and anti-P-ERK antibodies performed on sagittal sections from control tg-TOM (A) and tumor bearing tg-BRAF^V600E-TOM adult zebrafish at 12 mpf (B) (20X magnification). Arrows indicate sites of carcinoma invading skeletal muscle, inset is 40X magnification of skeletal muscle invasion. (C) High magnification photomicrographs of H&E-stained sections from tg-BRAF^V600E-TOM animals. Key diagnostic features of papillary thyroid carcinoma are observed: nuclear grooves (arrows), elongated nuclei (arrows), desmoplastic stromal reaction (asterisk) and crowded nuclei (60X magnification).

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