FIGURE

Fig. 3

ID

ZDB-FIG-170517-35

Publication

Anelli et al., 2017 - Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression

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Fig. 3

BRAF^V600E expression in thyrocytes leads to transcriptional upregulation in genes associated with EMT and TGF-β signaling.

(A) Schematic diagram of the FACS-sorting workflow with the experimental plots indicating the percentage of TdTomato-positive cells sorted from tg-TOM and tg-BRAF^V600E-TOM. (B) Heat-map depicting top differentially expressed genes (Figure 3—source data 1) in sorted tg-BRAF^V600E-TOM compared to tg-TOM. (C,D) Gene set enrichment plots of TGF-β and EMT signatures from RNAseq performed on sorted thyrocytes from tg-BRAF^V600E-TOM and tg-TOM larvae (E.S.=0.503, FDR = 0.011, nominal p-val = 0.002 and E.S.=0.344, FDR = 0.035, nominal p-val = 0.0, respectively).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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