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ZFIN ID: ZDB-FIG-170206-16
Lu et al., 2017 - Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish. Developmental Biology   421(2):139-148 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Term:
Stage Range: Prim-5 to Long-pec
PHENOTYPE:
Fish:
Observed In:
Stage Range: Prim-5 to Long-pec

Fig. 1

LA1110 mutants exhibit a reduction in cardiomyocyte cell number. (A and B) Tbx20 mutant embryos (B) form a thin and small heart tube at 26hpf compared with that of wild-type siblings (A), as indicated by the fluorescent labeling of differentiated cardiomyocytes by the myl7:EGFP transgene. (C and D) Wild type embryos display a looped two-chambered heart at 48hpf (C), whereas LA1110 mutant embryos (D) exhibit a thin, stretched and string-like heart. (E) Graph of the average number of GFP-positive cardiomyocytes in wild type and LA1110 mutant embryos at 30hpf (n=5). Error bars indicate standard deviations. Asterisks indicate a significant difference (**p<0.01).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP twu34Tg control Prim-5 cardiac muscle cell IFL
Long-pec cardiac muscle cell IFL
twu34Tg ; tbx20la1110/la1110 control Prim-5 cardiac muscle cell IFL
Long-pec cardiac muscle cell IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
twu34Tg control Prim-5 heart tube decreased size, abnormal
twu34Tg control Prim-15 cardiac muscle cell decreased amount, abnormal
twu34Tg control Prim-15 heart hypoplastic, abnormal
twu34Tg control Long-pec heart hypoplastic, abnormal
twu34Tg control Long-pec heart straight, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 421(2), Lu, F., Langenbacher, A., Chen, J.N., Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish, 139-148, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.