FIGURE

Fig. 8

ID

ZDB-FIG-161222-37

Publication

Alvarado et al., 2016 - Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development

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Fig. 8

dlx1a and dlx2a expression is wdr68-dependent and responsive to inhibition of TGF-β signaling in wdr68^{hi3812/hi3812} zebrafish.

(A-H) ISH analysis of prim-12 stage embryos raised at 32°C. A-F) dlx2a expression with red underline for anterior portion of 1^st arch and blue underline for 2^nd arch. A, C, E) lateral view. B, D, F) dorso-lateral view. A, B) DMSO-treated wildtype sibling showing normal dlx2a. C, D) DMSO-treated wdr68^{hi3812/hi3812} mutant showing loss of anterior 1^st arch dlx2a. E, F) SB431542-treated wdr68^{hi3812/hi3812} mutant showing partial rescue of anterior 1^st arch dlx2a. G, H) dlx1a expression. G) wildtype sibling showing normal dlx1a. H) wdr68^{hi3812/hi3812} mutant showing loss of anterior 1^st arch dlx1a.

Expression Data

Genes:	dlx1a dlx2a
Fish:	WT dcaf7^{hi3812Tg/hi3812Tg}
Conditions:	heat exposure chemical treatment by environment: SB 431542, heat exposure
Anatomical Terms:	pharyngeal arch 1 pharyngeal arch 1 anterior region pharyngeal arch 1 cranial neural crest pharyngeal arch 2 cranial neural crest
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dcaf7^{hi3812Tg/hi3812Tg}
Conditions:	heat exposure chemical treatment by environment: SB 431542, heat exposure
Observed In:	pharyngeal arch 1 pharyngeal arch 1 anterior region
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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