FIGURE

Fig. 9

ID

ZDB-FIG-160725-7

Publication

Prabhudesai et al., 2016 - LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 9

LRRK2 knockdown causes mislocalization of the Na⁺/K⁺ ATPase protein in the kidneys. A,B: Immunofluorescence images of 10-µm sections of 60 hpf wt embryos (A) and LRRK2 morphants (B) injected with the LRRK2 translational MO and stained using a Na⁺/K⁺ ATPase antibody and DAPI. The Na⁺/K⁺ ATPase is localized to the basolateral side of the cells in sections from wt embryos. In contrast, the Na⁺/K⁺ ATPase is localized to the apicolateral side of the cells in sections from LRRK2 morphants.

Expression Data

Antibody:	Ab1-atp1a1
Fish:	AB AB + MO3-lrrk2
Knockdown Reagent:	MO3-lrrk2
Anatomical Terms:	pronephric duct apicolateral plasma membrane pronephric duct basolateral plasma membrane
Stage:	Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO3-lrrk2
Knockdown Reagent:	MO3-lrrk2
Observed In:	pronephric duct apicolateral plasma membrane pronephric duct kidney epithelium development
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurosci. Res.