FIGURE

Fig. 7

ID

ZDB-FIG-160601-11

Publication

David et al., 2016 - G-quadruplexes as novel cis-elements controlling transcription during embryonic development

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Fig. 7

Effect of nog3 G-quadruplex disruption by nog3-ASO injection in zebrafish embryos. (A) Numbers and percentages of embryos showing dead, deformed, normal or small head phenotypes are shown in a table and represented in a stacked bar graph for 48-hpf staged embryos injected with CTRL or nog3-ASO. ***P < 0.001, chi-square test. (B) Representative picture of Alcian Blue staining of craniofacial cartilages in 4-dpf staged larvae injected with CTRL or nog3-ASO. Ventral views, anterior to the left. (C) Box-plots of the relative ceratohyal cartilages angle and ceratobranchial cartilages number of 4-dpf staged larvae injected with CTRL or nog3-ASO. *P < 0.05, t-Student test. (D) WISH assessing the expression of nog3 mRNA in 56-hpf staged larvae injected with CTRL (i) or nog3-ASO (ii). Arrowheads point regions of lower expression. In lateral and dorsal views anterior is to the left. Numbers and percentages of embryos/larvae with the shown phenotype are indicated in each panel. ca: ceratohyal cartilages angle; cb (3-7): ceratobranchial cartilages 3 to 7; ch: ceratohyal cartilage; pa: pharyngeal arches; pf: pectoral fin; tc: trabeculae cranii. Scale bars (200 µm) are represented in B and Di.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.