FIGURE

Fig. 6

ID

ZDB-FIG-160601-10

Publication

David et al., 2016 - G-quadruplexes as novel cis-elements controlling transcription during embryonic development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Effect of fzd5 G-quadruplex disruption by fzd5-ASO injection in zebrafish embryos. (A) Numbers and percentages of embryos showing dead, deformed, normal or reduced-eye phenotypes are shown in a table and represented in a stacked bar graph for 30-hpf staged embryos injected with CTRL or fzd5-ASO. ***P < 0.001, chi-square test. (B) Representative picture of 30-hpf staged embryos injected with CTRL or fzd5-ASO used to determine eye diameter. Lateral views, anterior to the left. (C) Box-plot of the relative eye diameter of 30-hpf staged embryos injected with CTRL or fzd5-ASO. ***P < 0.001, t-Student test. (D) WISH assessing the expression of fzd5 mRNA in 2-somite (i and ii), 10-somite (iii and iv), 15-somite (v and vi) and 30-hpf (vii and viii) staged embryos injected with CTRL (i, iii, v and vii) or fzd5-ASO (ii, iv, vi and viii). Arrowheads point regions of lower expression. In lateral views anterior is to the left, and in fronto-dorsal views anterior is up. Numbers and percentages of embryos/larvae with the shown phenotype are indicated in each panel. e: eye; vdc: ventral diencephalon. Scale bars (200 µm) are represented in B, Di, Diii, Dv and Dvii.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.