FIGURE

Fig. S15

ID

ZDB-FIG-160316-41

Publication

Xu et al., 2016 - Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration

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Fig. S15

Fhl1b blocks induction of late-forming ventral bud-derived endocrine cells.

(A-C′) Confocal images of control embryos without SU5402 (A and A′) and with SU5402 (B and B′) treatment as well as fhl1b-overexpressing embryos with SU5402 treatment (C and C′, heat shock applied at 50 hpf) at 72 hpf, stained for Islet (red) and Cadherin (blue). Upon treatment of Fgf receptor inhibitor SU5402, ectopic Islet-positive endocrine cells appeared in the hepatopancreatic ductal system (HPD) (B and B′, white asterisks). This effect was blocked by overexpression of fhl1b (C and C′). The white lines depict the junction between the pancreas and the HPD. A-C, confocal projection images. A′-C′, confocal single-plane images. Ventral views, anterior to the top. Scale bar, 20 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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