FIGURE

Fig. 7

ID

ZDB-FIG-151204-3

Publication

Pagán et al., 2015 - Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment

Other Figures

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Fig. 7

Restoring CSF-1R Signaling during an Ongoing Infection Delays Granuloma Necrosis

(A) Schematic of temperature-shifting experiment.

(B-D) Macrophage numbers (B), bacterial cording (C), and bacterial burdens (D) in phenotypically WT heterozygotes (csf1r^ts/+), csf1r null homozygous mutants (csf1r^-/-), and temperature-sensitive heterozygotes (csf1r^ts/-). Horizontal lines indicate means. Statistical significance was determined by one-way ANOVA with Tukey’s post-test (B and D) or Fisher’s exact test, correcting for multiple comparisons by multiplying p values obtained in pairwise comparisons by the number of groups in each experimental condition (C).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	csf1ra^{j4blue/j4blue} csf1ra^utr4e174A/+; csf1ra^j4blue/+
Condition:	heat exposure
Observed In:	blood island macrophage macrophage
Stage Range:	Day 4 to Days 7-13

Phenotype Detail

Acknowledgments

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