ZFIN ID: ZDB-FIG-151110-15
D'Aniello et al., 2015 - Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS One   10:e0138588 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec

Fig. 4 Rdh10a depletion enhances defects in nls/aldh1a2 mutant embryos.

(A, D) WT control and Rdh10a deficient embryos. (B,E) Control and Rdh10a deficient embryos heterozygous for the nls allele. (C,F) Control and Rdh10a deficient embryos homozygous for the nls allele. Nls mutant embryos (C) show anteriorization of nervous system (black arrowhead), increases in the size of the head (black bracket), and pericardial edema. Rdh10a deficient; nls mutant embryos (F) have an accentuated anteriorization of the nervous system (arrowhead), larger and dysmorphic head (red bracket), and enhanced pericardial edema compared to nls embryos. Dorsal is up and anterior is to the right.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
aldh1a2i26/i26 standard conditions Long-pec head increased size, abnormal
Long-pec nervous system wholly anterioralized, abnormal
Long-pec pericardium edematous, abnormal
Long-pec whole organism decreased length, abnormal
aldh1a2i26/i26 + MO1-rdh10a + MO2-rdh10a + MO4-tp53 standard conditions Long-pec head increased size, abnormal
Long-pec nervous system wholly anterioralized, abnormal
Long-pec pericardium edematous, abnormal
Long-pec whole organism decreased length, abnormal
Acknowledgments:
ZFIN wishes to thank the journal PLoS One for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS One