FIGURE

Fig. 7

ID

ZDB-FIG-151110-18

Publication

D'Aniello et al., 2015 - Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis

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Fig. 7

Comparison of RA, RAL, and ROL teratogenicity.

(A-J) Embryos at 48 hpf that were treated from sphere stage through 24 hpf with DMSO, ROL, RAL, and RA. (D,G) Low concentrations of RAL (0.1 µM) and ROL (10 µM) did not cause significant overt defects. (B,E,H) Intermediate concentrations of RAL (1 µM) and ROL (20 µM) and the lower concentration of RA (0.025 µM) produced truncated embryos that still had eyes (arrows). (C,F,I) 0.05 µM RA, 2 µM RAL, and 40 µM ROL produced severely truncated embryos without eyes.

Expression Data

Expression Detail

No data available

Antibody Labeling

No data available

Phenotype Data

Fish:	WT
Conditions:	chemical treatment: all-trans-retinoic acid chemical treatment: all-trans-retinal chemical treatment: all-trans-retinol
Observed In:	caudal fin eye head
Stage:	Long-pec

Phenotype Detail

Fish	Conditions	Stage	Phenotype
WT	chemical treatment: all-trans-retinoic acid	Long-pec	caudal fin truncated, abnormal
WT	chemical treatment: all-trans-retinoic acid	Long-pec	caudal fin wholly posteriorized, abnormal
WT	chemical treatment: all-trans-retinoic acid	Long-pec	eye decreased size, abnormal
WT	chemical treatment: all-trans-retinoic acid	Long-pec	head decreased size, abnormal
WT	chemical treatment: all-trans-retinal	Long-pec	caudal fin truncated, abnormal
WT	chemical treatment: all-trans-retinal	Long-pec	caudal fin wholly posteriorized, abnormal
WT	chemical treatment: all-trans-retinal	Long-pec	eye decreased size, abnormal
WT	chemical treatment: all-trans-retinal	Long-pec	head decreased size, abnormal
WT	chemical treatment: all-trans-retinol	Long-pec	caudal fin truncated, abnormal
WT	chemical treatment: all-trans-retinol	Long-pec	caudal fin wholly posteriorized, abnormal

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Acknowledgments

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