FIGURE

Fig. 8

ID

ZDB-FIG-151008-22

Publication

Hu et al., 2015 - Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Increased p21b^CIP1/WAF1 expression in homozygous ddb1^m863 mutants.

(A-B) Enhanced expression of p21b^CIP1/WAF1 (cdkn1a) in ddb1^m863 homozygous embryos in the proliferation regions of the optic tectum, compared to wild type siblings at 36 hpf. (C-D) At 48 hpf, p21b^CIP1/WAF1 expression was strongly elevated in proliferation regions of the optic tectum, cerebellum, telencephalon, retina, branchial arches and pectoral fin bud in ddb1^m863 mutants compared to wild type siblings. In contrast, expression of p21b^CIP1/WAF1 in ventral hindbrain nuclei (arrow heads in B, D) was unaltered in ddb1^m863 mutants. All views are lateral except for inserts (dorsal views). Abbreviations used: Cce, cerebellum; H, hypothalamus; L, lens; pfb, pectal fin bud; ret, retina; tel, telencephalon; TeO, tectum opticum. Anterior towards the left. Scale bar: 100 µm.

Expression Data

Gene:	cdkn1a
Fish:	WT ddb1^m863/m863
Anatomical Terms:	brain cerebellum eye hindbrain nucleus lens midbrain midbrain ventral region midbrain hindbrain boundary optic tectum proliferative region pectoral fin bud pharyngeal arch 3-7 retina ventricular zone
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One