FIGURE

Fig. 5

ID

ZDB-FIG-151008-19

Publication

Hu et al., 2015 - Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

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Fig. 5

Increase of p53 transcript levels in ddb1^m863 mutants.

(A-D) Lateral (A-D) and dorsal views (inserts in A, C) of p53 expression pattern in embryos at 36 hpf (wt, n = 30; mut, n = 8) and 48 hpf (wt, n = 25; mut, n = 11). The transcription of p53 was prominently enhanced in ddb1^m863 mutant embryos. Anterior towards the left. Abbreviations used: ba, branchial arches; Cce, cerebellum; end, endoderm, H, hypothalamus, hb, hindbrain; j, jaw; pfb, pectoral fin bud; tel, telencephalon; TeO, tectum opticum. Scale bar: 100 µm

Expression Data

Gene:	tp53
Fish:	WT ddb1^m863/m863
Anatomical Terms:	cerebellum ciliary marginal zone diencephalon dorsal region endoderm hindbrain inner ear midbrain midbrain hindbrain boundary optic tectum proliferative region pectoral fin bud pharyngeal arch 3-7 pharyngeal arch 3-7 proliferative region proliferative region retina telencephalon ventricular zone (all 16)
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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