Fig. 5
- ID
- ZDB-FIG-140409-18
- Publication
- Eroglu et al., 2014 - An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development
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HSBP1-MO-treated zebrafish embryos exhibit increased cellular domains expressing markers representing NC inducers. In situ hybridization analyses showing the expression of the indicated genes in the embryos at 12 hpf stage. (A) Expression of NC inducers in control MO- and HSBP1 MO1 and MO2-injected embryos. In all panels, dorsal views of the embryos show expression of Tfap2a, Snail2 or Foxd3. A total of 2000 embryos were injected and 100 embryos were used per probe for the in situ hybridization analyses. No nonspecific hybridization was observed with sense probes (data not shown). Morphant phenotypes were more than 90%, n=40. Mag. 40×. (B) Quantification of the expression of NC inducers in control MO- and HSBP1 MO1-injected embryos. For data quantification, photos were subdivided and the number of squares was quantified in both Y and X-axis. In the lower panels, numbers in the X-axis correspond to the numbers in the upper panels. |
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| Stage: | 5-9 somites |
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| Stage: | 5-9 somites |
Reprinted from Developmental Biology, 386(2), Eroglu, B., Min, J.N., Zhang, Y., Szurek, E., Moskophidis, D., Eroglu, A., and Mivechi, N.F., An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development, 448-460, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.