FIGURE

Fig. 7

ID

ZDB-FIG-131220-16

Publication

Balow et al., 2013 - Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome

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Fig. 7

Gene expression changes in cell-cycle regulators in chd7/fbxl10 double morphants. (A) Expression of pre-rRNA in chd7/fbxl10 double morphants and fbxl10 single morphants (re-plotted for comparison from Fig. 5H) relative to Std morphants at 8 hpf (n=3). (B-D) Graphs of qRT-PCR data measuring gene expression of several cell cycle regulator genes at 25 hpf across the panel of morphant embryos relative to Std morphants (n=5-6). Expression data for chd7 morphants re-plotted here from Fig. 4 F-H for comparison. Error bars represent SEM. Significance for all graphs was determined with a Student′s two-tailed t-test and significant values are noted p<0.05 (*), p<0.01 (**), p<0.001 (***).

Expression Data

Genes:	cdkn1a cdkn1bb cdkn2a/b
Fish:	TU TU + MO1-kdm2bb + MO3-chd7
Knockdown Reagents:	MO1-kdm2bb MO3-chd7
Anatomical Term:	whole organism
Stage Range:	1-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 382(1), Balow, S.A., Pierce, L.X., Zentner, G.E., Conrad, P.A., Davis, S., Sabaawy, H.E., McDermott, B.M., and Scacheri, P.C., Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome, 57-69, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.