Gene

cdkn2a/b

ID
ZDB-GENE-081104-306
Name
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
Symbol
cdkn2a/b Nomenclature History
Previous Names
  • cdkn2b
  • ink4b (1)
  • si:dkey-123o10.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Is expressed in digestive system; eye; heart; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdkn2a/b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
melanoma and neural system tumor syndrome Alliance {Melanoma and neural system tumor syndrome} 155755
{Melanoma, cutaneous malignant, 2} 155601
{Melanoma-pancreatic cancer syndrome} 606719
Associated With cdkn2a/b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily
UniProtKB:A0A2R8PZV6 129
UniProtKB:E9QFU2 125
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdkn2b monoclonal IgG2a Rat
  • IHC
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations