Gene

cdkn2a/b

ID

ZDB-GENE-081104-306

Name

cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)

Symbol

cdkn2a/b Nomenclature History

Previous Names

cdkn2b
ink4b (1)
p16 (1)
si:dkey-123o10.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Is expressed in eye; intestinal bulb; mid intestine; posterior intestine; and telencephalon. Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A) and CDKN2B (cyclin dependent kinase inhibitor 2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdkn2a/b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
melanoma and neural system tumor syndrome	Alliance	{Melanoma and neural system tumor syndrome}	155755
		{Melanoma, cutaneous malignant, 2}	155601
		{Melanoma-pancreatic cancer syndrome}	606719

Associated With cdkn2a/b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR050776	Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat