FIGURE

Fig. 6

ID

ZDB-FIG-131105-21

Publication

Rosenfeld et al., 2013 - Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Hspb7 is required for establishment of left–right asymmetry. (A–C) Representative in situ hybridization expression patterns of the left–right asymmetry markers lft1 (A), lft2 (B), or spaw (C). Panels in (A) and (B) show, left to right, normal (leftward), bilateral, or right-sided expression in embryos at the 22-somite stage. Panels in (C) are likewise, but the embryos are at the 18 somite stage, and some hspb7 morphants show a partial pattern of bilateral expression (far right panel). All views are dorsal, with anterior to the top. (D–F) Quantification of these phenotypes, and in each case n is at least 18 embryos.

Expression Data

Genes:	lft1 lft2 spaw
Fish:	WT + MO1-hspb7
Knockdown Reagent:	MO1-hspb7
Anatomical Terms:	heart primordium heart rudiment
Stage Range:	14-19 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-hspb7
Knockdown Reagent:	MO1-hspb7
Observed In:	determination of heart left/right asymmetry
Stage Range:	14-19 somites to 20-25 somites

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 381(2), Rosenfeld, G.E., Mercer, E.J., Mason, C.E., and Evans, T., Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis, 389-400, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.