FIGURE

Fig. S3

ID

ZDB-FIG-130802-10

Publication

Koltowska et al., 2013 - Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis

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Fig. S3

Ssrp1a promotes differentiation and proliferation of the zebrafish eye. (A-F) Retinal ath5 expression in ssrp1as819 mutants is indistinguishable from controls at 30 hpf (A,B), but severely reduced at later stages (C-F). Lateral views, anterior to the right. (K-L′) BrdU incorporation in the eye is severely compromised in mutants compared to wild-type. Coronal sections with anterior to the top. (G-J) ptf1a in differentiating amacrine cells fails to be expressed in ssrp1^as819 mutants compared with controls at 40 hpf, whereas expression in the exocrine pancreas and CNS is indistinguishable (G,H). At 52 hpf, ptf1a expression is not detectable in any tissue of ssrp1^as819 mutants (I,J). Lateral views, anterior to the right. (M) Genetic depletion of Tp53 significantly rescues cell death in Ssrp1a-deficient cells in the eye. Error bars represent s.d.

Expression Data

Genes:	atoh7 ptf1a
Fish:	WT ssrp1a^s819/s819
Anatomical Terms:	anterior pancreatic bud central nervous system amacrine cell eye eye amacrine cell retina
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ssrp1a^s819/s819
Observed In:	camera-type eye development eye eye cell division
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

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