FIGURE

Fig. 3

ID

ZDB-FIG-130802-14

Publication

Koltowska et al., 2013 - Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis

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Fig. 3

Ssrp1a promotes cell cycle progression. (A-C) BrdU incorporation is reduced in ssrp1a^s819 mutant livers from 38 hpf onwards (outlined). Error bars represent s.d. (D-G) Transgenic cecyil expression marks G₁ phase cells in red and S/G₂/M phase cells in green. (H) Quantification of hepatoblast proliferation shows a reversed distribution in controls and ssrp1a^s819 mutants at 48 hpf. (I) FACS analysis of 42-44 hpf foregut endoderm shows an increase of cells in S phase and a decrease of those in G₁ phase in ssrp1a^s819 mutants. A-B′,D-G are confocal projections of ventral views; all anterior to the top. ^*P<0.05, ^***P<0.0005, determined by unpaired Student’s t-test.

Expression Data

Genes:	mAGFP mKOFP2
Antibody:	Ab3-prox1
Fish:	rw0405bTg; rw0410hTg ssrp1a^s819/s819; rw0405bTg; rw0410hTg
Anatomical Term:	liver
Stage Range:	Prim-25 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ssrp1a^s819/s819; rw0405bTg; rw0410hTg
Observed In:	positive regulation of cell cycle
Stage Range:	Prim-25 to High-pec

Phenotype Detail

Acknowledgments

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