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ZIRC
ZFIN ID: ZDB-FIG-121214-11
Li et al., 2012 - SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development (Cambridge, England)   139(23):4321-4329 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: Prim-5 to Day 6
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 1 Impairment of definitive hematopoiesis in tangohkz5 mutant zebrafish. (A,B) WISH of rag1 in 6 dpf tangohkz5/hkz5 embryos and wild-type siblings. Arrows indicate the thymus. (C-H) WISH of hbae1, lyz and flk1 in 25 hpf tangohkz5/hkz5 mutant embryos and wild-type siblings. (I-L) WISH of hbae1 and lyz in 5 dpf and 6 dpf tangohkz5/hkz5 mutant embryos and wild-type siblings. Blue arrows indicate the position of the kidney; black arrows indicate the CHT.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
hbae1.1 WT standard conditions Prim-5 erythroid lineage cell ISH
Day 5 hematopoietic system posterior side ISH
Day 5 kidney ISH
sae1hkz5/hkz5 standard conditions Prim-5 erythroid lineage cell ISH
Day 5 hematopoietic system posterior side ISH
Day 5 kidney ISH
kdrl WT standard conditions Prim-5 endothelial cell ISH
sae1hkz5/hkz5 standard conditions Prim-5 endothelial cell ISH
lyz WT standard conditions Prim-5 myeloid cell ISH
Day 6 hematopoietic system posterior side ISH
Day 6 kidney ISH
sae1hkz5/hkz5 standard conditions Prim-5 myeloid cell ISH
Day 6 hematopoietic system posterior side ISH
Day 6 kidney ISH
rag1 WT standard conditions Day 6 thymus ISH
sae1hkz5/hkz5 standard conditions Day 6 Not Detected thymus ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
sae1hkz5/hkz5 standard conditions Day 5 definitive hemopoiesis disrupted, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development