Gene
hbae1.1
- ID
- ZDB-GENE-980526-80
- Name
- hemoglobin, alpha embryonic 1.1
- Symbol
- hbae1.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to act upstream of or within oxygen transport. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including cardiovascular system; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBA1 (hemoglobin subunit alpha 1) and HBZ (hemoglobin subunit zeta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 122 figures from 80 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha thalassemia | Alliance | Thalassemias, alpha- | 604131 |
| familial erythrocytosis 7 | Alliance | Erythrocytosis, familial, 7 | 617981 |
| Heinz body anemia | Alliance | Heinz body anemias, alpha- | 140700 |
| hemoglobin H disease | Alliance | Hemoglobin H disease, nondeletional | 613978 |
| Methemoglobinemia, alpha type | 617973 |
1 - 5 of 5
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin, alpha-type | Hemoglobin and related oxygen transporters | Hemoglobin, pi |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZT21 | InterPro | 143 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | hbae1-001 (1) | Havana | 877 nt | ||
| mRNA |
hbae1.1-201
(1)
|
Ensembl | 633 nt | ||
| mRNA | ottdart00000002407 (1) | Havana | 555 nt | ||
| mRNA | ottdart00000002419 (1) | Havana | 838 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-5K11 | ZFIN Curated Data | |
| Contained in | BAC | XX-BY119C3 | ||
| Contained in | PAC | BUSM1-118J2 | ||
| Encodes | EST | bn0aa053ze07 | ZFIN Curated Data | |
| Encodes | EST | fa12a11 | Gates et al., 1999 | |
| Encodes | EST | fb74f06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86936 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173767 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173768 | ZFIN Curated Data |
1 - 9 of 9
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BE693186 (1) | 659 nt | ||
| Genomic | GenBank:AL935210 | 88933 nt | ||
| Polypeptide | UniProtKB:Q7ZT21 (1) | 143 aa |
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Han, X., He, W., Liang, D., Liu, X., Zhou, J., de Thé, H., Zhu, J., Yuan, H. (2024) Creg1 Regulates Erythroid Development via TGF-β/Smad2-Klf1 Axis in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(33):e2402804
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Ling, Y., Wu, J., Liu, Y., Meng, P., Sun, Y., Zhao, D., Lin, Q. (2024) Establishment of a Diamond-Blackfan anemia like model in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(10):906-921
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Chen, X.K., Yi, Z.N., Lau, J.J., Ma, A.C. (2023) Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis. Autophagy. 20(4):830-846
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
1 - 10 of 163
Show