Gene

hbae1.1

ID
ZDB-GENE-980526-80
Name
hemoglobin, alpha embryonic 1.1
Symbol
hbae1.1 Nomenclature History
Previous Names
  • ae1a (1)
  • hba2
  • HBA2r
  • HbA (1)
  • HBAA1 (1)
  • hbae1
  • hbae1a (1)
  • alphae1globin (1)
  • etID40432.3 (1)
  • globin alphae1 (1)
  • si:by119c3.1
  • si:by119c3.3
  • si:xx-119c3.3
  • wu:fa12a11
  • wu:fb74f06 (1)
  • zgc:86936 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to localize to haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; presumptive blood; and renal system. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1).
Genome Resources
Note
None
Expression
All Expression Data
103 figures from 66 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hbae1.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alpha thalassemia Alliance Thalassemias, alpha- 604131
familial erythrocytosis 7 Alliance Erythrocytosis 7 617981
Heinz body anemia Alliance Heinz body anemias, alpha- 140700
hemoglobin H disease Alliance Hemoglobin H disease, nondeletional 613978
Methemoglobinemia, alpha type 617973
Associated With hbae1.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000971 Globin
Family IPR002338 Haemoglobin, alpha-type
Family IPR002339 Haemoglobin, pi
Homologous_superfamily IPR009050 Globin-like superfamily
Homologous_superfamily IPR012292 Globin/Protoglobin
Domain Details Per Protein
Protein Length Globin Globin-like superfamily Globin/Protoglobin Haemoglobin, alpha-type Haemoglobin, pi
UniProtKB:Q7ZT21 143
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations