FIGURE

Fig. 3

ID

ZDB-FIG-120907-9

Publication

Xing et al., 2012 - Zebrafish foxP2 Zinc Finger Nuclease Mutant Has Normal Axon Pathfinding

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Fig. 3

foxP2 mutant has normal morphology and CNS patterning.

Whole-mount embryos, brightfield images, scale bar = 50 μm. Lateral views, rostral to the left (A-F); dorsal views, rostral to the top (G, H). (A, B) Gross head morphology is unchanged in mutants at 72hpf. Arrow in (B) shows line used to measure brain size, from the midbrain-hindbrain boundary to the edge of the head by dissecting the midpoint of the lens. (C-D) mRNA expression of foxP2 transcript is unchanged in intensity and pattern in foxP2 mutants. (E-H) in situ expression patterns and intensity of zic2a and dlx2 is unchanged in mutants compared to wild-type embryos.

Expression Data

Genes:	dlx2a foxp2 zic2a
Fish:	WT foxp2^zc82/+; foxp2^zc83/+ foxp2^zc82/+; foxp2^zc84/+ foxp2^zc83/+; foxp2^zc84/+
Anatomical Term:	central nervous system
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxp2^zc82/+; foxp2^zc83/+ foxp2^zc82/+; foxp2^zc84/+ foxp2^zc83/+; foxp2^zc84/+
Observed In:	brain
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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