Gene

foxp2

ID
ZDB-GENE-041203-2
Name
forkhead box P2
Symbol
foxp2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamma-aminobutyric acid signaling pathway; response to ethanol; and swimming behavior. Predicted to be active in nucleus. Is expressed in central nervous system; head; and heart tube. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
speech-language disorder-1 Alliance Speech-language disorder-1 602081
1 - 1 of 1
Associated With foxp2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR032354 FOXP, coiled-coil domain
Domain IPR047412 Forkhead box protein P1/P2, forkhead domain
Family IPR050998 Forkhead box protein P
1 - 5 of 7 Show all
Domain Details Per Protein
Protein Additional Resources Length Forkhead box protein P Forkhead box protein P1/P2, forkhead domain Fork head domain Fork head domain conserved site 2 FOXP, coiled-coil domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q4JNX5 InterPro 697
UniProtKB:A0AB32TLD3 InterPro 698
UniProtKB:A0AB32TNW7 InterPro 692
UniProtKB:A0AB32TQ67 InterPro 605
UniProtKB:A0AB32TQV9 InterPro 668
1 - 5 of 6 Show all
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA foxp2-201 (1)
Ensembl
Ensembl 2,379 nt
ZFIN BLAST
mRNA foxp2-202 (1)
Ensembl
Ensembl 2,376 nt
ZFIN BLAST
mRNA foxp2-204 (1)
Ensembl
Ensembl 602 nt
ZFIN BLAST
mRNA foxp2-205 (1)
Ensembl
Ensembl 2,725 nt
ZFIN BLAST
ncRNA foxp2-005 (1)
Ensembl
Ensembl 979 nt
ZFIN BLAST
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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