Gene

foxp2

ID

ZDB-GENE-041203-2

Name

forkhead box P2

Symbol

foxp2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in response to ethanol. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Is expressed in head; heart tube; and nervous system. Orthologous to human FOXP2 (forkhead box P2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
speech-language disorder-1	Alliance	Speech-language disorder-1	602081

Associated With foxp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR032354	FOXP, coiled-coil domain
Domain	IPR047412	Forkhead box protein P1/P2, forkhead domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead box protein P1/P2, forkhead domain	Fork head domain	Fork head domain conserved site 2	FOXP, coiled-coil domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:Q4JNX5 InterPro	697

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	foxp2-202 (1) Ensembl	Havana	2376 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	foxp2-204 (1) Ensembl	Havana	602 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	foxp2-205 (1) Ensembl	Havana	2725 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	foxp2-005 (1) Ensembl	Havana	979 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	foxp2-009 (1) Ensembl	Havana	573 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations