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ZIRC
ZFIN ID: ZDB-GENE-041203-2
Gene Name: forkhead box P2
Gene Symbol: foxp2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in response to ethanol. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Is expressed in head; heart tube; and nervous system. Orthologous to human FOXP2 (forkhead box P2).
Genome Resources: Alliance (1),  Gene:555242 (1),  Ensembl(GRCz11):ENSDARG00000005453 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa121 Point Mutation Unknown Premature Stop ENU
sa152 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa190 Point Mutation Unknown Premature Stop ENU
    sa11787 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13041 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33376 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40221 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zc82 Small Deletion Exon 2 Unknown ZINC_FINGER_NUCLEASE
    zc83 Small Deletion Exon 2 Unknown ZINC_FINGER_NUCLEASE
    zc84 Insertion Exon 2 Unknown ZINC_FINGER_NUCLEASE
    PHENOTYPE
    Data: Fig. 4 from Xing et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH foxp2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    speech-language disorder-1 Alliance Speech-language disorder-1 602081
    DISEASE ASSOCIATED WITH foxp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to ethanol (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxp2-202 (1)    Ensembl 2376
    foxp2-204 (1)    Ensembl 602
    foxp2-205 (1)    Ensembl 2725
    ncRNA foxp2-005 (1)    Ensembl 979
    foxp2-009 (1)    Ensembl 573
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxp2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(foxp2.A1:EGFP) foxp2 EGFP Danio rerio 1 3
    Tg(foxp2.A2:EGFP) foxp2 EGFP Danio rerio 1 3
    Tg(foxp2.A2:EGFP-CAAX) foxp2 EGFP Danio rerio 1 6
    Tg(foxp2.A2:GAL4-VP16,myl7:EGFP) foxp2myl7 EGFPGAL4VP16 Danio rerio 1 7
    Tg(foxp2.A:EGFP) foxp2 EGFP Danio rerio 2 12
    Tg(foxp2.B:EGFP) foxp2 EGFP Danio rerio 1 3
    Tg(foxp2.D:EGFP) foxp2 EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    foxp2 Contained in: [BAC] CH211-262N1 (1) (order this), DKEY-112E7 (1) (order this), DKEY-116L11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001030082 (1) 2777 bp
    Genomic GenBank:CR356233 (1) 146900 bp
    Select Tool
    Polypeptide UniProtKB:Q4JNX5 (1) 697 aa
    Sequence Clusters UniGene:106317 (1)
    Sequence Information (all 14)
    ORTHOLOGY for foxp2 ( Chr: 4 )
    CITATIONS (36)