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ZFIN ID: ZDB-FIG-120214-5
Malicki et al., 1996 - Mutations affecting development of the zebrafish retina. Development (Cambridge, England)   123:263-273
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Protruding-mouth to Day 5

Fig. 7

Mutants involving retinal degeneration associated with a general pigmentation defect. Mutant individuals (lower) are shown next to their wild-type siblings (upper). (A,B,C) piegus(pgu)m286. (D,E,F) punktata(pkt)m288. (G,H,I) mizerny(miz)m293. All three mutants have abnormal melanocytes and reduced eye size. Sections through mutant retinae at 3 dpf (C,I) and 5 dpf (F) reveal an excessive amount of cell death. (J,K,L) Higher magnification of the dorsal retina in the wild type (J), pgum286 (K) and mizm293 (L). Cell corpses appear as small, round, intensely staining particles (arrows in K and L). In pktm288 and mizm293 the photoreceptor cell layer has abnormal appearance (F,I). A, D and G show lateral views; B, E and H dorsal views. The dorsal side is oriented up in panels showing lateral views or sections. In panels showing head phenotypes anterior is left. All sections are transverse.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mizm293/m293(AB) standard conditions Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina apoptotic, abnormal
Protruding-mouth retinal photoreceptor layer morphology, abnormal
Day 5 brain shape, abnormal
Day 5 eye decreased size, abnormal
Day 5 melanocyte circular, abnormal
Day 5 melanocyte condensed, abnormal
Day 5 otolith decreased size, abnormal
Day 5 pigmentation process quality, abnormal
pgum286/m286(AB) standard conditions Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina apoptotic, abnormal
Day 5 eye decreased size, abnormal
Day 5 melanocyte circular, abnormal
Day 5 melanocyte condensed, abnormal
Day 5 otolith decreased size, abnormal
Day 5 pigmentation process quality, abnormal
pktm288/m288(AB) standard conditions Day 5 brain shape, abnormal
Day 5 eye decreased size, abnormal
Day 5 melanocyte circular, abnormal
Day 5 melanocyte condensed, abnormal
Day 5 otolith decreased size, abnormal
Day 5 retina apoptotic, abnormal
Day 5 retinal photoreceptor layer morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.